COMBINED EXOSOMES & MICRONEEDLING TREATMENT

What is the combined Exosomes and Microneedling treatment and how does it work?

 

The combined Exosomes and Microneedling is an advanced regenerative skin treatment that pairs medical microneedling with Ameela® plant-derived Exosomes, polynucleotides (PDRN), growth factors, collagen and peptides.

 

Microneedling creates controlled micro-channels in the skin, stimulating natural collagen production and allowing targeted delivery of regenerative actives. Applying Ameela Exosomes immediately after microneedling significantly enhances penetration, cellular communication and skin repair, resulting in healthier, stronger and more resilient skin.

 

 

What are Exosomes?

 

Exosomes are microscopic extracellular vesicles naturally released by cells. They act as cell-to-cell messengers, carrying bioactive molecules such as proteins, lipids and RNA that influence repair, regeneration and inflammation control.

 

In aesthetic medicine, Exosomes are used to accelerate healing, improve skin quality, and optimise regenerative responses, particularly when combined with treatments such as microneedling.

 

 

What makes Ameela exosomes different?

 

Ameela Exosomes are derived from plant sources (not human or animal tissue) such as grapefruit and watermelon, and are combined with additional regenerative ingredients, including:

• Plant-derived Exosomes rich in signalling molecules and antioxidants

• Wild Salmon PDRN (polydeoxyribonucleotide) to support DNA repair and hydration

• Ameela Growth Factors to stimulate renewal processes

• Hexapeptide-8 to soften expression lines

• Collagen support to enhance structure and barrier function

 

This combination has been developed to support collagen synthesis, reduce oxidative stress, improve hydration and resilience, and encourage a brighter, smoother complexion.

 

 

Plant exosomes vs human exosomes – what’s the difference?

 

Plant-derived Exosomes (Ameela)

• Sourced from fruits (grapefruit & watermelon)

• No human or animal tissue involved

• No risk of donor-derived viruses, prions or pathogens

• Extremely low immunogenicity

• Ethically uncomplicated and sustainable

• Highly stable and consistent between batches

 

Human or animal Exosomes

• Often derived from stem cells, placental tissue or animal sources

• Carry ethical concerns around donor tissue use

• Potential variability between donors

• Theoretical risk of immune reactions or pathogen transmission

 

From both a safety and ethical standpoint, plant-derived Exosomes offer a more controlled, reproducible and transparent option for patients seeking regenerative treatments without the concerns associated with human-derived products.

 

 

Why combine Exosomes with Microneedling?

 

Microneedling alone stimulates collagen and elastin production. When combined with Ameela Exosomes:

• Absorption of active ingredients is maximised through the micro-channels

• Cellular repair signals are enhanced

• Inflammation is reduced

• Tissue repair and renewal are accelerated

• Skin tone, texture and hydration are optimised

 

This synergistic pairing often produces more noticeable and longer-lasting improvements than microneedling alone.

 

 

How is Exosomes and Microneedling treatment different to PRP or skin boosters?

 

• PRP relies on your own platelet quality, which varies between individuals

• Skin boosters primarily hydrate but do not actively modulate cellular repair pathways

• Exosomes actively communicate with skin cells, enhancing regeneration, repair and resilience at a molecular level

 

Combined with microneedling, Exosomes offer a more comprehensive regenerative approach.

 

 

What skin concerns does the combined Exosomes and Microneedling treatment help with?

 

This treatment can be used for a number of medical conditions as well as for cosmetic reasons:

• Fine lines and early wrinkles

• Uneven texture and tone

• Enlarged pores

• Dull, tired or dehydrated skin

• Redness and compromised barrier

• Early signs of ageing

• Skin recovery after inflammatory or cosmetic procedures

 

It is ideal for patients who want natural-looking improvement in overall skin quality rather than dramatic structural change.

 

 

Which areas can be treated with Exosomes and Microneedling?

 

This treatment can enhance several vital areas, including the:

• Face

• Neck

• Décolletage

• Hands

 

Treatment plans are always tailored following a full consultation.

 

 

How soon will I see the results of Exosomes and Microneedling treatment?

 

Results often begin with improved hydration and glow within 1–2 weeks, with progressive improvement in texture, firmness and skin quality over 4–8 weeks, followed by continued collagen stimulation for several months.

 

 

How many Exosomes and Microneedling treatments will I need?

 

The number of treatments required varies based on individual skin concerns and goals.

 

Typically, a series of 3-4 treatments spaced 2-4 weeks apart is recommended for optimal results.

 

Maintenance treatments are typically recommended every 6–9 months for sustained benefits. 

 

 

 

What are the side effects of Exosomes and Microneedling treatment?

 

Like all medicines, this treatment can produce unwanted effects.

 

Common, temporary side-effects include slight redness and warmth, mild swelling, slight sensitivity of tightness of the skin, and light flaking or dryness as the skin renews. These usually resolve within 24–72 hours.

 

Serious side effects are rare, such as allergic reactions. It is important to follow post-treatment care instructions and contact Dr Lauren if you experience any unusual reactions.

 

 

What is the downtime after Exosomes and Microneedling treatment?

 

The recovery period is typically short. Most patients can resume normal activities within 24–48 hours. Makeup can usually be worn after 24 hours.

 

 

Can Exosomes and Microneedling treatment be combined with other treatments?

 

Yes, Exosomes and Microneedling treatment can be combined with other aesthetic procedures such as hyaluronic acid fillers, Botox, and Polynucleotides to achieve more comprehensive results.

 

Dr Lauren will create a personalised treatment plan to address your specific needs.

 

 

Am I a candidate for Exosomes and Microneedling treatment?

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This treatment is suitable for most skin types, but a consultation is necessary to determine personal suitability.

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This treatment is not suitable for women who are pregnant or breastfeeding.

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This treatment may not be suitable for patients who:

• Have used Roaccutane (Isotretinoin) within the last six months;

• Are on blood thinning medication (e.g. aspirin, warfarin);

• Are taking over-the-counter medication that can thin the blood or increase bruising (Omega-3, Vitamin E, Cod liver oil, Garlic, St. John’s Wort, Ginkgo Biloba);

• Have Eczema, Psoriasis, active Acne, Rosacea, or other chronic skin conditions in the area to be treated;

• Are wanting treatment for scars that are less than six months old;

• Have had facial Botox or fillers injected within the last six weeks;

• Have had a chemical peel within the last two weeks;

• Have open wounds, cuts, abrasions, sunburn, or active skin infection in the area requiring treatment;

• Have had radiation treatment to the skin on or around the area to be treated within the last year;

• Are prone to Herpes Simplex or Zoster infections as treatment can trigger breakouts;

• Have raised moles, warts, or lesions within the area to be treated;

• Have any history of keloid or hypertrophic scars, or are prone to poor wound healing;

• Have a history of Scleroderma, or Collagen Vascular Disease;

• Have a history of Immunosuppression;

• Have an Autoimmune Disease;

• Have a known hypersensitivity to any of the ingredients of the product, or who have multiple confirmed allergies.

 

 

Is the Exosomes and Mircroneedling treatment painful?

 

Most patients report minimal discomfort during the procedure. Most patients describe the sensation during treatment as pressure or mild scratching rather than pain. A topical numbing cream can be applied to the treatment area to enhance comfort.

 

 

Advice prior to Exosomes and Microneedling treatment

 

• For seven days prior to treatment, avoid blood thinning over-the-counter medication such as aspirin, or ibuprofen-based medications, Omega-3, Vitamin E, Garlic, St. John’s Wort, Ginkgo Biloba. If you are prescribed a blood thinning medication such as aspirin or an anticoagulant by your doctor for a cardiovascular condition, then please check with your doctor prior to stopping the medication.

• For two weeks prior to treatment, avoid waxing or chemical depilatories in the area to be treated.

• For one week prior to treatment, avoid excessive sun exposure or the use of sunbeds.

• For 48 hours prior to treatment, avoid using topical products containing retinol, AHA’s (eg glycolic acid), acidic or “active” ingredients.

• For 24 hours prior to treatment, do not drink alcohol to avoid extra bruising.

• On the day of treatment, arrive to the clinic with a clean face and free of make-up. 

 

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What to expect on the day of Exosomes and Microneedling treatment

 

• Dr Lauren will go through what your aims are for treatment and will explain to you what is appropriate and achievable. A treatment plan will be agreed upon prior to treatment.

• You will fill in a medical assessment questionnaire and complete a written consent form.

• Pre-treatment photographs will be taken for your medical records.

• Numbing cream may be applied to the area if required.

• Any make-up will be removed from treatment area if needed, and the area will be cleaned with chlorhexidine solution.

• Microneedling will be performed with a designated microneedling roller attached to a syringe that will apply the Ameela Exosomes serum topically throughout your treatment. The needle depth will vary depending on the area treated - usually a 1.00mm needle depth is used for most treatment areas, and a 0.25mm needle depth is used for the undereye area.

• Post-procedure cream will be applied to the treated area following treatment.

• You will be given a post-treatment advice sheet.

• Dr Lauren will let you know if any further treatments or follow-up is required.

• Appointment time is usually 30-45 minutes. An additional 5 minute numbing appointment time 30-45 minutes prior to your treatment may be arranged if indicated.

 

 

Exosomes and Microneedling treatment aftercare instructions

 

• Don’t apply foundation or creams over the treatment area for 6 hours after your treatment.

• Avoid strenuous exercise first 24 hours or hot tubs.

• Avoid alcohol for 24 hours after your treatment.

• You should avoid make-up for 24 hours after your treatment.

• Refrain from using harsh skincare products for a few days, eg retinol, AHA’s (eg glycolic acid), acidic or “active” ingredients.

• Wear a broad spectrum, high factor (30 or above) SPF, and avoid direct sun exposure for at least the first 48 hours after treatment.

• You should also refrain from exercise, hot tubs, and saunas for 48 hours.

• Avoid saunas or tanning booths for 2 weeks after your treatment, as well as other heat treatments such as radiofrequency, IPL, or laser.

• Bruising can be helped by taking oral bromelain (pineapple extract) and oral arnica, or by applying arnica cream.

• Any skin colour changes, such as an area of skin becoming purple or red, or bruising which appears abnormal, please contact the clinic immediately.

 

 

How can I book a consultation?

 

To book a consultation and learn what treatment is right for you, please contact the clinic directly on 0141339 7579.